The global drug discovery services market the size should go from 9,324.1 million USD in 2020 at $18,562.4 million by 2027, at a CAGR of 9.8% from 2021 to 2027. Drug discovery services are the services required for drug development by various pharmaceutical and biotechnology companies. Molecular manipulation, random screening, drug metabolites, molecular design, and serendipity are commonly used methods for drug development. This process includes seeker identification, generation, representation, selection, and testing for therapeutic utility.

Factors such as growing pipelines of biologic candidates, continued outsourcing from pharmaceutical companies, and increasing demand for precise drug analytical details and process development by regulatory agencies are expected to drive the rapid growth of the market. With changing market dynamics, service providers strive to deliver analytical testing of quality, accuracy, and robustness within tight timelines. Rising research and development spending, increased focus on cost optimization, a growing trend towards outsourcing, big data, artificial intelligence, and global pharmaceutical and biotech companies looking for more and more dynamic, flexible and reliable partners are some factors that increase the growth of the market across the globe.

Since most drugs are used to treat critically ill patients with chronic illnesses, the drug usually must strictly adhere to the standards set by regulatory bodies. Strict regulatory requirements mean that many countries have long lead times for approving pharmaceutical drugs, especially for cancer drugs. There are significant differences when regulators in different countries approve drugs based on their prevailing national regulatory standards. This means that, in general, patients have access to promising drugs (such as drugs for cancer and other chronic diseases) at different times. This severely limits the marketing ability of most large companies. Additionally, late approval in countries means that many patients are missing out on potentially important drugs to improve their quality of life.

Global Drug Discovery Services Market Dynamics

Drivers: increase investment in research and development for the development of new drug molecules

The research and development expenditure of pharmaceutical companies has increased over the years. For example, Pfizer spent $7,690 million on research and development in 2015, which rose to $8,650 million in 2019. This translates directly into increased spending on drug discovery. According to a 2020 report published by the American Medical Association (JAMA) Journal, the estimated median capitalized R&D cost per product between 2009 and 2018 is valued at $985 million, including expenses related to failed trials.

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In the case of new therapies, the number of searches is also increasing. According to the research paper published in Pharmaceuticals in February 2020, three peptides, Active Pharmaceutical Ingredients (APIs), have been approved by the FDA. Forty-eight drugs were approved in 2019, 10 of which were biologics, and the remaining 38 new chemical entities (NCEs) included peptides and oligonucleotides.

Constraints: strict government regulations

Regulatory agencies normally only approve cancer drugs based on randomized, controlled, double-blind Phase 3 trials. These trials take a long time and can sometimes involve a large number of people. Thus, strict standards also impede rapid approval of the company-to-market pipeline. Additionally, the primary concern for regulatory approval is the wide variability in current clinical trial design, including different inclusion criteria, endpoints, analysis plans, and definition of best care. concurrent supports; due to these variations, differing opinions on what should be considered a meaningful clinical endpoint by the European Medicines Agency (EMA) versus the US Food and Drug Administration (FDA).

Opportunities: Advancement in technologies

The use of advanced technologies, such as artificial intelligence, bioinformatics and pharmacogenomics, plays a vital role in reducing the time required for drug discovery, which benefits pharmaceutical companies with reduced investments and a return on increased investment. Artificial intelligence is about developing intelligent algorithms that can mimic the environment commonly associated with the human brain. Thus, artificial intelligence has affected all aspects of pharmaceutical business, from the process of early-stage drug discovery and clinical development to the commercialization of the drug in the market.

Advances in data analytics are expected to drive the adoption of various modern approaches in drug discovery, such as adaptive assay design, master protocols, improved segmentation of diseases and patient populations, applications of real-world evidence (RWE) for regulatory approval, which can increase the efficiency of R&D and the quality of evidence generated to support drug approval.

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Report scope

The study categorizes the drug discovery services market based on process, type, drug type, therapeutic area, and business type.

By process (Revenue, billion USD, 2017-2027)

• Target selection
• Target validation
• Hit-To-Lead Identification
• Lead Optimization
• Validation of candidates

By Type (Revenue, USD Billion, 2017-2027)

• Medicinal Chemistry Services
• Biology services
• Drug metabolism and pharmacokinetics

By Drug Type (Revenue, Billion USD, 2017-2027)

• Small molecule drugs
• Biological drugs

By Therapeutic Area (Revenue, USD Billion, 2017-2027)

• Oncology
• Central nervous systems
• Cardiovascular
• Infectious disease
• Metabolic disorders
• Others

By Company Type (Revenue, USD Billion, 2017-2027)

• Tier 1 Pharmaceutical Companies
• Tier 2 Pharmaceutical Companies
• Tier 3 Pharmaceutical Companies

By Region (Revenue, USD Billion, 2017-2027)

• North America (United States, Canada, Mexico)
• South America (Brazil, Argentina, Colombia, Peru, Rest of Latin America)
• Europe (Germany, Italy, France, UK, Spain, Poland, Russia, Slovenia, Slovakia, Hungary, Czech Republic, Belgium, Netherlands, Norway, Sweden, Denmark, Rest of Europe)
• Asia-Pacific (China, Japan, India, South Korea, Indonesia, Malaysia, Thailand, Vietnam, Myanmar, Cambodia, Philippines, Singapore, Australia and New Zealand, Rest of Asia-Pacific)
• The Middle East and Africa (Saudi Arabia, United Arab Emirates, South Africa, North Africa, Rest of MEA)

The hit-to-lead identification segment of the drug discovery services market is expected to account for the largest share, by process

Based on this process, the drug discovery services market has been segmented into target selection, target validation, lead identification, lead optimization and candidate validation. The hit-to-lead identification segment held the dominant position, with the largest share of 28.7% of the global drug discovery services market in 2020. The large share of the hit-to-lead identification segment can be attributed to the increase in research-based high-throughput screening (HTS). The hit to lead (H2L) stage of drug discovery aims to uncover leads from a selection of compounds that demonstrate certain promising therapeutic effects. This includes a detailed analysis of a chemical library comprising smaller molecules with possible activity at the target site.

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Asia-Pacific accounts for the highest CAGR over the forecast period in the drug discovery services market.

Based on regions, the global drug discovery services market has been segmented into North America, Asia-Pacific, Europe, South America, and Middle East & Africa. In Asia-Pacific, four main countries, namely China, India, Japan and the rest of Asia-Pacific, are analyzed. Asia-Pacific ranks second in the global drug discovery services market. China accounted for a large share of this market in 2020, and India is expected to grow rapidly over the forecast period.

The Asia-Pacific region is also estimated to exhibit the fastest CAGR of 11.9% in the drug discovery services market during the forecast period. Rising growth prospects in emerging APAC countries and a shift in the research and manufacturing base of major pharmaceutical companies are expected to propel regional growth during the forecast period. Additionally, several prominent pharmaceutical giants have entered the APAC region to reduce manufacturing costs and tap growth opportunities in the near future.

Main market players

The drug discovery services market is slightly concentrated in nature with few global players operating in the market, such as Thermo Fisher Schientific, Merck KGaA, Charles River Laboratories International, GE Healthcare, Evotec, Jubilant Biosys, Covance, Genscript Biotech Corporation, Aurigene Discovery Technologies, Wuxi Apptec, Syngene, Eurofins Scientific, Laboratory Corporation of America Holdings, GVK Biosciences Private Limited, Lonza Group AG, Piramal Enterprises Ltd., Dalton Pharma Services, Viva Biotech and Selvita. Among these market players, Charles River Laboratories, Laboratory Corporation of America Holdings, Wuxi Apptec, Thermo Fisher Scientific, and Evotec are some of the prominent players in the drug discovery services market. These companies contribute approximately 46.3% of the global market, with a major presence in the United States.